منابع مشابه
Platelets interact with bacterial pathogens.
Thromb Haemost 2009; 102: 613–614 The predominant role of platelets is in haemostasis. Resting platelets patrol the vasculature and become activated in response to endothelial cell damage and exposure to subendothelial matrix components, such as collagen or von Willebrand factor. Adhesion and activation result in the release of the contents of platelet granules, and in the upregulation of surfa...
متن کاملInteractions of periodontal pathogens with megakaryocytic cells and platelets
Introduction: Cardiovascular disease (CVD) is a leading cause of morbidity, accounting for around 17.3 million deaths worldwide. Recent studies have linked periodontitis to CVD with the periodonto-pathogens Porphyromonas gingivalis and Tannerella forsythia thought to contribute and exacerbate atherosclerosis through interactions with platelets. To date, while platelet activation following chall...
متن کاملThe role of platelets in defence against pathogens.
Many more platelets are present in healthy mammals than are necessary for routine haemostasis. Thus, they could have other functions. Platelets have many of the attributes of innate immune function including Toll-like receptors. They also contain a wide range of anti-microbial peptides in storage granules. Platelets play an important role in bacterial infections, both in disease progress and in...
متن کاملThe source of HLA molecules on platelets: Does platelets adsorb soluble HLA molecules from their environment?
Background: The origin and function of human leukocyte antigen (HLA) class I molecules on platelets are still highly arguable. Given the differences in the results of the previous studies in this regard, the lack of research in recent years, and the clinical importance of HLA class I molecules, the absorption capacity of platelets for soluble HLA class I molecules was studied in this investigat...
متن کاملPLATELETS AND THROMBOPOIESIS Anucleate platelets generate progeny
1Program in Human Molecular Biology and Genetics and 2Department of Surgery, University of Utah, Salt Lake City; 3Department of Nanoscale Imaging of Cellular Dynamics, Courant Research Centre Nano-Spectroscopy and X-Ray Imaging, University of Göttingen, Göttingen, Germany; 4Department of Physics and Harvard School of Engineering and Applied Sciences, Harvard University, Cambridge, MA; 5Division...
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ژورنال
عنوان ژورنال: Cellular and Molecular Life Sciences
سال: 2009
ISSN: 1420-682X,1420-9071
DOI: 10.1007/s00018-009-0204-2